The harmonized microbial limits test

Microbial extremophiles at the limits of life.

Prokaryotic extremophiles were the first representatives of life on Earth and they are responsible for the genesis of geological structures during the evolution and creation of all currently known ecosystems. Flexibility of the genome probably allowed life to adapt to a wide spectrum of extreme environments. As a result, modern prokaryotic diversity formed in a framework of physico-chemical fac...

Power limits for microbial life

To better understand the origin, evolution, and extent of life, we seek to determine the minimum flux of energy needed for organisms to remain viable. Despite the difficulties associated with direct measurement of the power limits for life, it is possible to use existing data and models to constrain the minimum flux of energy required to sustain microorganisms. Here, a we apply a bioenergetic m...

The Application of Steam Quality Test Limits

Public good diffusion limits microbial mutualism.

Standard game theory cannot describe microbial interactions mediated by diffusible molecules. Nevertheless, we show that one can still model microbial dynamics using game theory with parameters renormalized by diffusion. Contrary to expectations, greater sharing of metabolites reduces the strength of cooperation and leads to species extinction via a nonequilibrium phase transition. We report an...

International GLP: a critical reflection on the harmonized global GLP standard from a test facility viewpoint.

The implementation of the Organisation for Economic Co-operation and Development (OEC D) principles of good laboratory practice (GLP) on an international level is well advanced. However, the OEC D GLP guidelines as well as the corresponding national GLP regulations leave room for interpretation. As a consequence, working in parallel in GLP environments in several countries represents a challeng...